Scientific Research and Real Facts about the Cannabinoids in Cannabis

Posted: November 4, 2013 in One People's Public Trust (OPPT)
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Published on Feb 12, 2013

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Marijuana, Cannabis and Cannabinoid Research

PubMed – Cannabinoid Research

ncbi.nlm.nih.gov/pmc/articles/PMC3442177

ncbi.nlm.nih.gov/pmc/articles/PMC2828614

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ncbi.nlm.nih.gov/pmc/articles/PMC2604798

Cholangiocarcinomas are cancers that have poor prognosis and limited treatment options. The noncanonical Wnt pathway is mediated predominantly by Wnt 5a, which activates a Ca2+-dependent pathway involving protein kinase C, or a Ca2+-independent pathway involving the orphan receptor Ror2 and subsequent activation of Jun NH2-terminal kinase (JNK). This pathway is associated with growth-suppressing effects in numerous cell types. We have shown that anandamide decreases cholangiocarcinoma growth in vitro. Therefore, we determined the effects of anandamide on cholangiocarcinoma tumor growth in vivo using a xenograft model and evaluated the effects of anandamide on the noncanonical Wnt signaling pathways. Chronic administration of anandamide decreased tumor growth and was associated with increased Wnt 5a expression in vitro and in vivo.

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